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Additional info for 2008 Kaplan USMLE Step 1 Home Study Program-Brand New Volume II: General Principles Book 2

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As the liver grows into the abdomen, the ventral mesentery between the liver and ventral body wall becomes stretched and membranous and forms the falciform ligament. The free margin of the falciform ligament contains the umbilical vein, which, after birth, is obliterated to form a fibrous cord called the ligamentum teres. 2. Similarly, the ventral mesentery between the liver and the ventral stomach-duodenal border forms a membrane called the lesser omentum. The free margin of the lesser omentum contains the bile duct, portal vein, and hepatic artery.

Third pharyngeal pouch. The ventral wings of the paired third pharyngeal pouches give rise to the thymus, and the dorsal wings differentiate into the inferior parathyroid glands. 1. Thymus arises as a bilateral diverticulum, which grows inferiorly to the superior medi- astinum, solidifies, and fuses. a. Endodermal cells multiply to give rise to the epithelial reticulum of the thymus as well as Hassall's (thymic) corpuscles. b. Lymphoid tissue invades the thymus by the fourth week. 2. Inferior parathyroid glands develop as a proliferation of endodermal cells and travel with the thyroid to lie on the dorsal surface of this gland.

A sex chromosome, iiiBhical 45 Embryology l. Trisomy2l (Down syndrome) a. In some cases, the extra chromosome 21 is translocated or attached to another chromosome. A carrier parent (clinically normal) with 45 chromosomes who has a translocated chromosome 21 has an increased chance of having a child with the syndrome. b. Tiisomy 21 is characterized by mental deficienry, small skull size, upwardly slanting palpebral fissures, and a deep transverse crease across each palm. c. It is associated with an increased incidence of congenital heart defects, umbilical hernia, and duodenal atresia.

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