By Derrick Lonsdale
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Additional info for A Nutritionist's Guide to the Clinical Use of Vitamin B-1
Piloerection is extremely common and is pathognomonic of sympathetic overdrive. The adolescent who complains bitterly of the cold, even on a warm day, will usually demonstrate vascular changes, particularly in the feet and lower legs. Such patients are often unable to go swimming, even in the heat of the summer, for they are unable to get warm and will sit in the sun with cyanotic lips and fingernails, teeth chattering, and shivering. There may be mottled vasculanty and even peripheral acrocyanosis, cold clammy skin, and poor capillary refill following blanching by digital pressure.
TRANSMETHYLATION The one carbon pool represents a group of compounds capable of transferring a methyl group to another compound and thus adding an additional carbon atom. Methionine is the most important methyl donor. Oxidative metabolism synthesizes ATP which is required to form S-adenosyl methionine (SAM) from methionine, and energy is therefore used. The labile methyl group is then passed on to a number of receptor compounds and homocysteine is formed. Homocysteine may be transulfurated or remethylated back to methionine to complete the cycle.
His studies revealed alterations in frequency, variability and character of respirations during sleep, and a decrease in the responsiveness of the respiratory centers to alterations in CO2 concentration. In five cases he reported the infants at risk had frequent episodes of sleep apnea, some associated with cyanosis and severe enough in some instances to require resuscitation. Two of the five infants subsequently died. 44 Naeye 45 described a 38-year-old patient whose death was attributed to the respiratory center associated with abnormalities in the pulmonary vascular bed.