Download Alkyl polyglucosides : from natural-origin surfactants to by Ivana Pantelic PDF

By Ivana Pantelic

The on-going ‘green’ development within the own care coupled with worldwide environmental issues, position natural-origin, biodegradable and skin-friendly surfactants reminiscent of alkyl polyglucosides (APGs) in excessive call for. After winning use in cosmetics, enough info has been received to welcome a few sugar emulsifiers into the sphere of drug dosage. Alkyl Polyglucosides provides a accomplished compendium which courses a researcher from the APG-related preformulation phases to formula processing, together with the research of assorted APG-stabilized structures pores and skin functionality. This booklet introduces a number of APG representatives, their advantages relating to yes traditional surfactants, physicochemical and interfacial houses, attainable interplay with accepted constituents and numerous characterization thoughts quintessential for the evaluate of colloidal structures. the 1st bankruptcy introduces alkyl polyglucosides, through chapters on their homes, behaviour, an summary of the patent defense mechanisms and directions for filing patent functions. eventually, a end surveys overseas patent purposes related to APGs.

    • introduces the sphere of alkyl polyglucoside emulsifiers, directory the entire modern and newly synthesized APG emulsifiers
    • provides certain info on quite a few points of APG-based buildings
    • reveals strength of APG-stabilized automobiles as potential supply platforms utilizing a number of version medicines and beauty actives
    • includes an up to date evaluate of analysis carried out within the box of APGs, facilitating destiny preformulation and formula reviews for researchers
    • offers a concise and functional compendium of characterization innovations

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      Extra info for Alkyl polyglucosides : from natural-origin surfactants to prospective delivery systems

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      A high level of correlation was obtained when melting transition temperatures were determined by rheological and microscopy methods. Another favourable property of APGs is their ability to form microemulsion systems, as previously mentioned, almost independently of temperature. , 1998) no temperature-dependent phase inversion can be expected to occur in APG-containing emulsions. , 2001). In a comprehensive study of Alkyl Polyglucoside microemulsion phase behaviour, Ryan and Kaler (2001) emphasized the industrial potential of APGs, particularly in the form of microemulsions.

      Alkyl Polyglucosides (APGs) show peculiar physicochemical behaviour, which affects their interfacial properties. For example, the phase behaviour of APG/water systems is only slightly influenced by temperature. Hence, no temperature-dependent phase inversion occurs in APG-containing emulsions. They may form thermotropic liquid crystalline phases on heating, and lyotropic liquid crystalline phases on addition of a solvent. In lyotropic liquid crystals, increasing alkyl chain length leads to destabilization of the hexagonal phase in favour of the lamellar one, which is interesting for pharmaceutical systems.

      Phase and aggregation behaviour of alkylglycosides. Curr Opin Colloid Interf Sci 2001; 6: 171–7. Holmberg K. Natural surfactants. Curr Opin Colloid Interface Sci 2001; 6: 148–59. Iglauer S, Wu Y, Shuler P, Yongchun T, Goddard III A. Alkyl polyglycoside surfactant–alcohol cosolvent formulations for improved oil recovery. Colloids Surf A Physicochem Eng Asp 2009; 339: 48–59. Jaksic I, Lukic M, Malenovic A, Reichl S, Hoffmann C, et al. Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization – A ketoprofen case study.

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