By Peter Elsner, Enzo Berardesca, Klaus-Peter Wilhelm
This article supplies an intensive creation within the organic foundation of pores and skin biomechanics. It explains the non-invasive tools that let size of the mechanical houses of the outside concentrating on commercially on hand tools. Written by means of the world over prime specialists within the box, this quantity describes the anatomy, biochemistry, body structure, and pathology of pores and skin biomechanics. It explains intimately how one can degree dermis mechanic homes and the way to exploit those measurements within the improvement of substances and cosmetics.
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Extra resources for Bioengineering of the Skin: Skin Biomechanics (Dermatology Clinical & Basic Science)
J. , 311,376-386,1984. Copyrighted Material 14 Bioengineering of the Skin: Skin Biomechanics 8. E. , The collagen family of proteins, in Connective Tissue Disease. Molecular Pathology of the Extracellular Matrix, Uitto, J. , Marcel Dekker, New York, 1987,3-28. 9. I. W. and Frederiksen. , Academic Press, New York, 1982,245-249. 10. , Collagen propeptides as indicators of collagen assembly, Acta. Orthop. , 66 (Supp1. 266), 183-188, 1995. 11. Prockop, DJ. , The collagen fibril: the almost crystalline structure, J.
The major components of BM are type IV collagen, a large heparin sulfate proteoglycan perlecan, and the glycoproteins laminin-I and nidogenlentactin. Laminins are large flexible cross-shaped glycoproteins composed of three polypeptide chains. They bind to type IV collagen, heparan sulfate, nidogen, and cell surface laminin receptor proteins. Type IV collagen forms a network that is important in the maintenance of the mechanical stability of BM. The binding of another independent network, formed by laminin-I on this network, is stabilized by nidogen-l and nidogen-2.
19. , 11, 115-120, 1989. 20. , The molecular basis of glucocorticoid-induced skin atrophy: topical glucocorticoid apparently decreases both collagen synthesis and the corresponding collagen mRNA level in human skin in vivo, Br. J. , 139, 1106-1110, 1998. 21. I.. , The biosynthesis of collagen and its disorders, New Engl. 1. , 301, 77-85, 1979. 22. MyllyHi, R. , Collagen and collagen-related diseases, Ann. , 33,7-21,2001. 23. , Ehlers-Danlos syndrome: recent advances and current understandino of the clinical and genetic heterogeneity, 1.