By Jose Rueff, António Sebastião Rodrigues
This quantity discusses the most recent developments and applied sciences utilized in melanoma drug resistance learn. Cancer Drug Resistance: Overviews and techniques contains chapters that disguise issues akin to: learning the mechanics of resistance to DNA destructive healing medicines; reports to delineate the function of efflux transporters; expression of drug transporters; resistance to specific remedies in breast melanoma; the position of microRNAs in present pancreatic melanoma therapy; and melanoma exosomes as mediators of drug resistance or medical and molecular equipment in drug improvement and using bioinformatics within the administration of melanoma drug resistance facts. Written within the hugely winning Methods in Molecular Biology series structure, chapters contain overviews of the most matters in melanoma drug resistance and the respective mechanisms, in addition to introductions to their respective issues, lists of the mandatory fabrics and reagents, step by step, without difficulty reproducible laboratory protocols, and tips about troubleshooting and keeping off identified pitfalls.
Authoritative and sensible, Cancer Drug Resistance: Overviews and Methods, is a important source to researchers, oncobiologists and medical oncologists or a person else who's attracted to the examine of melanoma and its drug resistances.
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Additional info for Cancer Drug Resistance: Overviews and Methods
5772/22944 Rodrigues AS, Gomes BC, Martins C, Gromicho M, Oliveira NG, Guerreiro PS, Rueff J (2013) DNA repair and resistance to cancer therapy. In: Chen C (ed) DNA repair and resistance to cancer therapy, new research directions in DNA repair. Intech. 5772/ 53952 Atchley DP, Albarracin CT, Lopez A, Valero V, Amos CI, Gonzalez-Angulo AM, Hortobagyi GN, Arun BK (2008) Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer. J Clin Oncol 26:4282–4288 Akashi-Tanaka S, Watanabe C, Takamaru T, Kuwayama T, Ikeda M, Ohyama H, Mori M, Yoshida R, Hashimoto R, Terumasa S, Enokido K, Hirota Y, Okuyama H, Nakamura S (2015) BRCAness predicts resistance to taxanecontaining regimens in triple negative breast cancer during neoadjuvant chemotherapy.
Ongoing difficulties include selection of appropriate tumors and measurement of the effects of the ABC transporter inhibitor on the pharmacokinetics of the cytotoxic drug. 5 Multidrug Resistance Mechanisms not Mediated by ABC Transporters Several additional classes of resistance to multiple anticancer drugs of differing structures have been defined. One involves the modification of the enzyme DNA topoisomerase II, a target protein for cytotoxic action. Cells were identified that lacked ABC transporter expression and yet were resistant to the drugs doxorubicin, etoposide, and amsacrine, which have widely differing structures.
Growth of this line in the absence of estrogen signaling causes an immediate cessation of culture growth, followed several months later by the outgrowth of hormone-resistant cell lines. Surprisingly, the G1-phase DNA content, median cell volume, and proliferation rates of the emerging variant lines were not the same as those of the parental cell line, strongly suggesting that they arose from expansion of pre-existing minor populations, rather than by metabolic adaptation of the parental population .