By Eggert Stockfleth MD PhD, Darrell S. Rigel MD, June K. Robinson MD, Merrick I. Ross MD, Robert Friedman MD MSc (Med), Clay J Cockerell, Henry Lim MD, John M Kirkwood MD
Cancer of the Skin, edited via Drs. Rigel, Robinson, Ross, Friedman, Cockerell, Lim, Stockfleth, and Kirkwood, is the entire, multimedia advisor to early prognosis and powerful scientific and surgical operation of cancer and different dermis cancers. completely up to date with eleven new chapters, this broad-based, finished reference offers you the most recent info on scientific genetics and genomics of epidermis melanoma, particular treatment for cancer, the nutrition D debate about the dangers and merits of sunlight publicity, and different well timed themes. a brand new, multi-disciplinary crew of individuals and editors constructed from major specialists during this box deals really various views and around the globe top practices.
- Broaden your figuring out of all points of epidermis cancer-from the underlying biology to scientific manifestations of the illness to analysis, and scientific and surgical treatment-with this easy-to-use, complete, multimedia reference.
- See stipulations as they seem in perform with counsel from designated full-color photos and step by step procedural video clips.
- Stay present with the newest developments and treatments! eleven new chapters disguise scientific genetics and genomics of pores and skin melanoma, specific treatment for cancer, the nutrition D debate about the hazards and advantages of sunlight publicity, and different crucial topics.
- Get actually diversified views and around the globe top practices from a brand new, multi-disciplinary crew of participants and editors constructed from the world’s top specialists
Access the total textual content online-including snapshot financial institution and video library-at www.expertconsult.com
Diagnose pores and skin melanoma successfully utilizing a multimedia reference with a multi-disciplinary process and the newest content material and techniques.
Read Online or Download Cancer of the Skin: Expert Consult - Online and Print, 2e PDF
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Additional info for Cancer of the Skin: Expert Consult - Online and Print, 2e
72. Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949–954. 73. Pollock PM, Harper UL, Hansen KS, et al. High frequency of BRAF mutations in nevi. Nat Genet. 2003;33(1):19–20. 74. Valverde P, Healy E, Jackson I, et al. Variants of the melanocytestimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat Genet. 1995;11(3):328–330. 75. Valverde P, Healy E, Sikkink S, et al. The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma.
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Murine keratinocytes expressing oncogenic RAS do not spontaneously develop SCCs; however, when challenged with UV irradiation, they develop SCCs, possibly because of the loss of p53. Similarly, when keratinocytes 16 lacking p19ARF (murine equivalent of the human p14ARF) are forced to express oncogenic RAS, invasive SCCs develop. As expression of p19ARF is known to result in the stabilization of p53, tumor formation upon the loss of p19ARF represents an alternative pathway to disrupt the function of p53.