By Mohammad Ali El-Darouti
The circumstances offered during this ebook will consultant the reader in the course of the strategy of creating a prognosis according to logical pondering. The publication offers a wealth of information concerning diagnostic techniques and pearls of knowledge. as well as strange shows of universal ailments, it comprises discussions approximately infrequent illnesses, complicated situations, outstanding diagnoses, healing demanding situations and different very important beneficial properties. changing into accustomed to such strange circumstances will give you the dermatologist with elevated wisdom, a much wider viewpoint, and leading edge suggestions that may be used to unravel diagnostic dilemmas. Readers will enhance their mind set and knowledge research, and may be capable of increase differential diagnoses. This e-book presents the original function of a strategic mind set whereas discussing each one case, as a way to succeed in a prognosis. The textual content contains comparisons of every case to different related instances, stating the distinguishing positive factors of stipulations lower than consideration.
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Extra resources for Challenging Cases in Dermatology
Differential Diagnosis • Alopecia universalis congenita (AUC). • Vitamin D- deficiency rickets (VDDR). 1 shows the differences and similarities between these differential diagnoses. Deﬁnite Diagnosis • The combination of total alopecia developed in the first year of life and papular lesions developing during childhood. • Exclusion of other causes of congenital total alopecia. Prognosis • Hair regrowth is not expected. Treatment • Due to the genetic pathogenesis of the disease, no effective treatment is known to induce re-growth of the hair.
Renal failure (rare). – Ectodermal dystrophy including nail dystrophy (rare). – Mild paronychia. – Xerosis. • Congenital hypothyroidism: – Presents as in APECED with alopecia,xerosis, and nail dystrophy but shows no mucocutaneous candidiasis. • Adverse reaction to tyrosine kinase inhibitors: – Also shows alopecia, xerosis and nail dystrophy but no mucocutaneous candidiasis. – It is of late onset and related to tyrosine kinase inhibitors. Deﬁnite Diagnosis • The disease is defined by the presence of two or more of the three major features: – Chronic mucocutaneous candidiasis.
Other therapeutic options are: the anti-histaminics, thalidomide, colchicine, corticosteroids and phototherapy (for the sclerotic plaques). Management of These Cases In these cases, the author had attempted treatment of the skin lesions and arthritis with colchicine and ultraviolet A light phototherapy (3 times/week), with two cases showing 50 % improvement of the indurations after 8 weeks. Message • Sclerotic hyperpigmented and hypertrichotic skin plaques are rare and recently described skin manifestation of Muckle-Wells Syndrome (MWS) that seems from the reported cases to occur exclusively in Orientals.