Download Cytokines as Potential Therapeutic Targets for Inflammatory by R. Numerof, Charles A. Dinarello, Khusru Asadullah PDF

By R. Numerof, Charles A. Dinarello, Khusru Asadullah

Cytokines and cytokine receptors stay a space of serious curiosity for the advance of certain remedies for cutaneous inflammatory ailments. Anti-TNF therapeutics have confirmed to be potent within the remedy of psoriasis, and medical investigations have now all started for different cytokine-directed treatments, equivalent to these concentrating on IFN-g, IL-12p40, and IL-18. as well as therapeutics that concentrate on cytokines at once, options that concentrate on cytokine signaling pathways are in improvement. This ebook summarizes the findings of the 56th overseas Workshop of the Ernst Schering examine origin that interested in "Cytokines as capability healing objectives for Inflammatory dermis Diseases".

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Extra resources for Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases (Ernst Schering Foundation Symposium Proceedings)

Sample text

Recent studies have elucidated the presence of numerous cytokine and chemokine activities in psoriatic skin and synovium. There is considerable interest in the potential of such activities as novel therapeutic targets. IL-15 is an innate response cytokine that activates leukocyte subsets via binding to its unique IL-15Rα and shared β and γ chain receptors. IL-15 promotes T cell memory and sustains local T cell activation, in part via prevention of apoptosis and mediates activation of monocytes, neutrophils and NK cells.

1990), and others. IFN-α can also induce underlying autoimmune 16 B. Skurkovich, S. Skurkovich diseases, including autoimmune thyroid disease (Murakami et al. 1999), type I diabetes (Fabris et al. 1998), and rheumatoid arthritis (Pittau et al. 1997). In multiple sclerosis, evidence points to IFN-γ as having a direct role in inducing central nervous system demyelination (Horwitz et al. 1997). IFN-γ in chronic high levels may set in motion the autoimmune process. Some pathological action is mediated by the induction by IFN-γ of nitric oxide synthetase, which produces nitric oxide (NO), which can cause neurodegeneration (Moncada et al.

G. the relative disappointment of IL-1 blockade in humans relative to animal model studies. Nevertheless, this approach provides a useful basis upon which to discuss cytokine activities proposed as potential targets in chronic inflammatory diseases. This chapter will describe the basic biology of interleukin-15, an innate response cytokine that exhibits broad functional pleiotropy and that has been implicated in inflammatory dermatoses and malignancies. Thereafter it will describe current understanding of the role played by IL-15 in autoimmunity.

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